This study shows the active principle that causes the heat in capsicum is a crystalline alkaloid generically called capsaicin. It induces the release of the substance (PSP) which is believed to play an important role in the murine hair growth cycle.
TITLE: Effect of Coapplication of Capsaicin and Minoxidil on the Murine Hair Growth
Won-Soo Lee, Hyung Jin Ahn, Young Hee Kim Department of Dermatology. Yonsei University Wonju College of Medicine, Wonju. Korea
Capsaicin induces the release of substance (PSP) which is believed to play an important role in murine hair growth and cycle. Minoxidil, the only approved topical hair drug having direct hair growth effect, has therapeutic limitation because it stimulates mainly vellus hair regrowth, not thick coarse terminal hairs... We devied the mice into 4 groups, i.e., control group, capsaicin group, minoxidil group, and coapplied group. And then, we examined the hair growth macroscopically, and the percentage of the area of hair regrowth by image analysis using phototrichogram at the 0, the 5th, 10th, 15th, 20th, 25th, and 30th day. Also we examined the morphologic changes of hair follicles and subcutis, and the number of mast cells by microscopy, and[methyl-3H] thymidine uptake by scintillation counter. In this study, we observed that capsaicin can not only induce the anagen phase quickly, but also sustain constant effect on the linear hair growth.